2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14186
    KVI-020 1000306-34-2 98%
    KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC50 of 480 nM. KVI-020 can inhibits hERG, with an IC50 of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research.
    KVI-020
  • HY-14834
    Budiodarone 335148-45-3 98%
    Budiodarone (ATI-2042) is an analogue of Amiodarone (HY-14187) with a half-life of 7 h. Budiodarone inhibits sodium, potassium, and calcium ion channels. Budiodarone is an antiarrhythmic agent and can be used for the research of atrial fibrillation.
    Budiodarone
  • HY-14878
    (2R)-Atecegatran 917904-13-3 98%
    (2R)-Atecegatran ((2R)-AZD-0837; (Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-Aze-Pab)) is a thrombin inhibitor. (2R)-Atecegatran can be used in research related to thromboembolic disorders.
    (2R)-Atecegatran
  • HY-14886
    Fasitibant chloride 1157852-02-2 98%
    Fasitibant chloride (MEN16132 free base) is a potent and selective nonpeptide bradykinin B2 receptor (B2R) antagonist. Fasitibant chloride reduces joint pain and diminishes joint oedema in Carrageenan-induced arthritis rat model.
    Fasitibant chloride
  • HY-14924
    Inakalant 335619-18-6 98%
    Inakalant is an atrial specific potassium channel blocker with antiarrhythmic activity. Inakalant works by selectively blocking potassium channels in heart cells, thereby prolongs the action potential duration (APD) of cardiomyocytes and increases the effective refractory period of the atria and ventricles, which helps to terminate and prevent the occurrence of arrhythmias such as atrial fibrillation (AF). Inakalant can be used in the study of arrhythmia and cardiac electrophysiology.
    Inakalant
  • HY-14936
    Sofigatran 187602-11-5 98%
    Sofigatran (MCC-977) is an orally active factor IIa (thrombin) inhibitor, acts as an anticoagulant. Sofigatran is used for the research of cardiovascular disease.
    Sofigatran
  • HY-15293
    JTV-519 1038410-88-6 98%
    JTV-519 (K201) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties.
    JTV-519
  • HY-15387
    Beclobrate 55937-99-0 98%
    Beclobrate (Sgd 24774), a Fibric acid derivative, displays remarkable lipid lowering activity in rodents.
    Beclobrate
  • HY-15402
    Edonentan 210891-04-6 98%
    Edonentan (BMS 207940) is an antagonist for endothelin receptor (ETA receptor), with a Ki of 10 pM. Edonentan is metabolic stable, exhibits good pharmakokinetic characters in rats. Edonentan regulates the endothelin system, blocks the big Endothelin-induced pressor response in rats model.
    Edonentan
  • HY-16213
    FURNIDIPINE 138661-03-7 98%
    FURNIDIPINE, an orally active cardio-protective agent, possesses anti-arrhythmic and antihypertensive effects.
    FURNIDIPINE
  • HY-16256
    Amrinone lactate 75898-90-7 98%
    Amrinone lactate is a positive inotropic-vasodilator agent. Amrinone lactate is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone lactate is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent.
    Amrinone lactate
  • HY-16259
    Indecainide hydrochloride 73681-12-6 98%
    Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent. Indecainide hydrochloride has Na+-channel-blocking activity.
    Indecainide hydrochloride
  • HY-16357
    Octimibate 89838-96-0 98%
    Octimibate is a non-prostaglandin platelet aggregation inhibitor and cycloprostaglandin agonist. Octimibate can be used in the study of cardiovascular diseases (atherosclerosis and thrombosis).
    Octimibate
  • HY-16461
    Solenopsin 137038-57-4 98%
    Solenopsin ((-)-Solenopsin A) is an ATP-competitive AKT inhibitor with IC50 value of 10 μM.
    Solenopsin
  • HY-16506
    Trimethaphan camsylate 68-91-7 98%
    Trimethaphan camsylate is an arterial blood pressure lowering agent that has been shown to reduce pulmonary venous pressure in experimental pulmonary edema.
    Trimethaphan camsylate
  • HY-16738
    Eleclazine 1443211-72-0 98%
    Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias.
    Eleclazine
  • HY-16952
    Bepridil 64706-54-3 98%
    Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells.
    Bepridil
  • HY-17497
    Acebutolol 37517-30-9 98%
    Acebutolol is an orally active β1 adrenergic receptor (β1AR) antagonist. Acebutolol is used for hypertension, angina pectoris and cardiac arrhythmias research.
    Acebutolol
  • HY-18100
    PRE-084 138847-85-5 98%
    PRE-084 is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway.
    PRE-084
  • HY-18205
    RXPA 380 564479-79-4 98%
    RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM.
    RXPA 380
Cat. No. Product Name / Synonyms Application Reactivity